Best Health Tips For Men And Women-New Hopes For Brain Disorder Treatments-According to the world health statistics, the health of the aging populations is slowly moving towards the ultimate betterment. However, this notion is still vague. As with growing age, the threat of neurological disorders like Parkinson’s and Alzheimer’s is on the rise without any way out for the permanent cure. If there is no cure for this type of brain disorder, and other associated neurological disorders, life seems to stand at a huge risk. And to conquer the freedom from this debilitating disease, a series of constant breakthrough researches must go on to find a solution and cure.
Causes Of Neurological Disorders
The Research Institute of Molecular Pathology recently conducted a study on the developing brain of mice to find the causes of neurological diseases. And the outcomes of the study may leave you stunned.
In order to find a relation between the brain function of the mice and the human, the scientists at the Research Institute of Molecular Pathology took the case of a young man from the European Country. He passed away at a tender age due to the certain mutation dysfunctions, which affected his brain and nerves and cognitive abilities as well as his ability to react to stimuli.
Finding Of The Study
The different associated nerve cell mechanisms such as their correct formation, differentiation, and migration influence the brains of the developing vertebrates. Similarly, the mutations can disrupt the functions of all the processes, which are too dependent on the arrangement of the genes and their accompanying proteins.
The scientists further found one of the genes known as Vps15 for the mutation inductions. And this gene is key to normal neurological development. However, as with the boy, it was the same gene that caused him to die, which is rare.
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Vps15- Causing Neurological Defects
The mutation causes defects in brain development in the developing mice. The molecular process that contains Vps15 also influences other corresponding proteins in the development of the cytoskeleton in the developing brain. And the connection between the Vps15 and proteins contribute to the neurodegenerative conditions as similar to the boy.
Hence, the further observation of the screening discovered that VPS15 when mutated influences the certain amount of proteins in the developing brain, and thus, contribute to the decline in neurodevelopment disorder. Other neurological complications may develop due to this specific gene or protein.
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Treatment Options
A ray of hope is there for the people with neurological development defects as the scientists at the Sanford Burnham Prebys Medical Discovery Institute target a new therapy using neural stem cell treatments.
The survival of neural stem cells depends on the modifications of mRNA. And this gene regulatory mechanism could lend its hands for the advancement of stem cell treatments to cure mental disorders like Parkinson’s and Alzheimer’s. Since mRNA modification maintains the self-renewal process of NSC, these progenitor cells can regulate their populations by self-renewal. It develops during the embryonic stage as well as the adult phase and is capable of differentiating other cell types too.
The modification of m6A helps NSC avoid premature differentiation. It is possible for m6A to regulate NSC mechanisms since it regulates the histone modification. Histone- a protein type also regulates the functions of DNA. And mRNA and histone could work together to curb the effects of the brain disorder. There is a long history that advocates for drugs using histones to aid in neurological disorder treatments.
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